Group revenue rose 13.8% to £1.04bn in the 24 weeks to 16 October, boosted in part by the ahead-of-schedule integration of its newly acquired Spirit Pub Company.
Greene King, which brews beers like Old Speckled Hen and Belhaven Best, bought the rival company in a deal worth £774m last year, creating one of the largest pub groups in Britain.
It helped statutory pre-tax profit rise 9% to £92.5m.
However, the company said both economic and regulatory challenges could hit the balance sheet.
The pubs group and brewer said it was working with trade organisations to urge the Government to offset some of the impact from initiatives like National Living Wage, National Minimum Wage, Apprenticeship Levy and proposed increases to business rates, which are expected to have an impact on costs and margins.
Those cost pressures could heap further pain on top of the effects of a weaker economy and softer discretionary spending in the wake of the Brexit vote.
Chief executive Rooney Anand said: "The full impact of the UK decision to leave the EU remains unclear.
"Looking ahead, increasing levels of consumer uncertainty, further cost pressures and the changing dynamics of eating out, mean the consumer environment is likely to become more challenging.
"However, we are confident that the strength of our brands, pubs, people and cash generation leaves us well placed to deliver another year of progress, value creation and returns for our shareholders."
Greene King employs around 43,000 people and operates around 3,029 pubs, restaurants and hotels across England, Scotland and Wales.