The airliner will fly up to three times weekly between Leeds Bradford and Cork operating ATR72 aircraft flying on a Tuesday, Thursday and Sunday.
Leeds Chamber president Gerald Jennings welcomed the new route, stating it will provide a major boost to the region’s exporters.
He said: “The Irish Republic is the fourth largest export market for Yorkshire companies and we expect that this new route to Cork will provide increased opportunities for bilateral trade.
“This announcement is welcome news.”
Jennifer Young, Visit Leeds associate director of visitor economy, added: “Visit Leeds welcomes the addition of this new route to Cork which will encourage and grow our inbound tourism links with SW Ireland.
“We expect that we will attract new visitors to Leeds to take advantage of the sporting and cultural offer alongside our shopping and retail experience.”
Flights go on sale on Tuesday 8 December with lead in fares of £24.99 one way including taxes.