Almost 230,000 people in the South East regularly work from home according to new analysis published by the TUC, representing 6.3% of the total workforce.
The region was third only to the South West (8.3% of the workforce) and the East of England (6.9% of the total workforce).
By contrast, Northern Ireland has the lowest proportion of homeworkers in the UK, with just 1 in 48 employees saying they regularly work at home.
The TUC’s general secretary Frances O’Grady believes there are many benefits to home-working, provided it is properly managed.
O'Grady said: "Modern home-working is good for the economy, as it helps businesses hold on to talented staff and boosts productivity. And it allows those with caring responsibilities or a disability greater access to the jobs market.
"While home-working may not work in all professions, I would urge employers to look at the value it can bring to their business and their workforce."
The industries with the highest shares of home workers are IT, agriculture and construction.