The shake-up will see experienced gaming executive Simon Wykes join the company as CEO.
Andy McIver is to step down from his role as CEO of Jackpotjoy, just six months after completing the successful listing of the company on the London Stock Exchange.
He will be replaced by experienced gaming executive, Simon Wykes, who will provide additional operational expertise.
Wykes has just completed an external consultancy role with Ladbrokes Coral on their merger integration plans.
He was previously chief executive officer at Gala Leisure and managing director at Gala Coral Group, where he oversaw the execution of a successful strategic turnaround plan of its bingo division.
His role however will involve working in the company's global markets with the senior management teams across each of the company's three business segments - Jackpotjoy, Vera&John, and Mandalay.
Jackpotjoy plc chairman Neil Goulden said: "Simon is a highly-experienced executive with an extensive knowledge of the bingo sector and considerable expertise in managing high-volume consumer businesses.
“His experience in the digitalisation of gaming businesses will be invaluable in achieving synergies across our main business segments and to drive the future growth of the group.
"On behalf of the board, I would also like to thank Andy for the commitment, leadership and integrity he showed during his tenure, which has seen Jackpotjoy plc cement itself as the world's largest online bingo-led company following its successful listing on the London Stock Exchange. We wish him well with his future endeavours."
Wykes added: "I am thrilled by this new challenge at Jackpotjoy plc and look forward to bringing my experience from leading digital gaming businesses to the company as well as significant operational experience to market leading brands."
Andy McIver will remain with the company until 31 Jan 2018 to ensure a smooth transition of duties to the new members of executive team.