A total of 1,920,084 people passed through the UK's third busiest gateway in April, marking an 11% year-on-year increase on April 2015.
The numbers were boosted in particular by Jet2.com launching new routes to Krakow and Naples and Monarch Airlines launching new services to Tel Aviv and Lisbon.
The airport also saw large number of football fans travelling through the airport due to Manchester City and Liverpool FC’s involvement in European competitions in April.
Amsterdam, Dublin, Dubai, Tenerife and Alicante were the most popular destinations, as passengers chose a mixture of city breaks and sunshine routes.
Ken O'Toole, Manchester Airport managing director, said: “It’s been another strong month for growth and it sets the tone for what we hope will be a record summer for Manchester Airport.
“April saw new route launches from Jet2.com and Monarch to the likes of Krakow, Naples and Tel Aviv and May sees the launch of direct flights to Los Angeles and Boston with Thomas Cook Airlines.
“There are many reasons people visit Manchester but football is one of the city's key selling points and when fans are here, we know they go on to spend money in hotels, bars, restaurants, cafes and other attractions.
“It is pleasing to see the airport playing such a positive role in driving the visitor economy of the North West in this way.
“With 22 million people in our catchment area we continue to offer passengers a wealth of destinations and options to suit every traveller.”
Freight was also up in April with a 9% increase, taking the rolling annual total to 104,228 tonnes.