Having already toured England and Wales, the bus is set to stop at Edinburgh on Monday, followed by Glasgow, Dundee, Aberdeen and finally Inverness.
The Edinburgh visit will see the bus stop at St Andrew Square in the city centre from 10am to 4pm and is free for all to get involved.
StartUp Britain campaign manager, Kosta Mavroulakis, told BQ:
"We've been really looking forward to bringing the StartUp Britain Bus to Scotland since launching the tour at Downing Street where we were joined by Jim Duffy and Carol Smillie from Entrepreneurial Spark.
"We've been overwhelmed with the support for the tour from the Scottish entrepreneurial ecosystem including Entrepreneurial Spark, Business Gateway, Bright Idea Scotland, Young Enterprise Scotland and many local business support organisations.
"These organisations and local entrepreneurs will be joining us on the bus in each of the 5 cities to provide free mentoring and advice to anyone with a business idea or existing business"
The StartUp Britain campaign was founded by eight entrepreneurs and launched on 28 March 2011 by the Prime Minister, with the full support of the Chancellor and HM Government.
The programme is now completely funded by their private sector sponsors, Sage, RBS and Upwork.
Scottish dates for the Startup Tour bus are as follows:
You can follow activity on Twitter: @StartUpBritain and #StartUpTour