The charity, which helps 30,000 volunteers each year gain work experience, will occupy two floors of the building and rent out a third floor.
Unity Trust Bank provided 70% of the mortgage, while Big Issue Invest Scotland – the social investment arm of the Big Issue magazine group – provided the remaining finance.
Harriet Eadie, chief executive at Volunteer Centre Edinburgh, said: “We recruit and place one in four of all volunteers in Edinburgh. It’s really exciting to now be a shop front presence in the heart of Edinburgh and we’ve already seen an increase in drop-in enquiries. This would certainly not have been achieved without the continual support of Unity Trust Bank, both in offering us a competitive loan and introducing us to the partnership with Big Issue Invest Scotland.”