If the plans come to fruition the IBG will be a ground-breaking commercial and residential property development built on 90 acres of land adjacent to the airport.
The consortium behind the project believes the development will attract more than £700m of onshore and international investment with over 7,000 construction and permanent jobs created over a 30-year period.
The submitting of the planning emphasises the commitment of the consortium, which is made up of two Edinburgh companies, Murray Estates and New Ingliston, and a joint-venture set up by Frogmore and Salmon Harvester.
Councillor Frank Ross, convenor of the economy committee on the City of Edinburgh Council, said: "The International Business Gateway is one of the most strategically important development propositions in Edinburgh and Scotland.
“The location’s connectivity is unmatched, with Edinburgh’s tram line linking it directly to the city centre and to Edinburgh Airport.
“Edinburgh Park business park and the global headquarters of the Royal Bank of Scotland are just minutes away.
“This is an exciting opportunity to deliver a flagship development that will help accommodate the city’s continued economic growth.
“I look forward to seeing the proposals in detail."
Should the planning application be approved, construction work is expected to start around the middle of 2017.