New flights to six European routes over the festive period helped to boost the figures, with Tenerife, Alicante and Malaga proving to be the most popular destinations.
As a direct result of the growth in passenger numbers, sales across retail and restaurant concessions increased by 15% during the month.
Mike Stewart, business development director, said: “There is still a lot of work to be done to get the airport on to a sound commercial footing but these latest figures show that the team is working hard to bring new business to Prestwick.
“It is important that we push on from here and continue to work with all our partners over the coming months as we look to identify new commercial opportunities for Glasgow Prestwick Airport.”
Going forward, the upward trend looks set to continue with the return of flights to Reus and additional flights to Pisa and Malaga confirmed for the summer season.
Early indications are that the Malaga flight will add an additional 4,400 passengers during the summer season from May to October.