The development, branded Magenta at Clyde Gateway, will include 1.2m sq ft of office space at the former Shawfield development.
The Magenta project, which is the largest office development with planning consent in the country, is being led by commercial property developer Highbridge Properties.
Clyde Gateway has invested £20m in public realm and infrastructure works to the site to ensure it is development-ready.
Ian Manson, chief executive at Clyde Gateway said: "This is an extremely exciting time for the Clyde Gateway area and I am delighted to have appointed Highbridge as our commercial development partner – a company with a fantastic track record in delivering high quality business parks".
"Magenta will give the local economy and employment market a phenomenal boost. It will also attract new inward investment to Scotland and stimulate economic growth."
"Neighbouring the Magenta site, Police Scotland has already seen the massive benefits of locating over 1,000 administrative, finance, and IT staff here and more and more companies are seeing first-hand why this area is such an attractive proposition for investment and the ideal location to do business."
It is expected that, as well as office space, Magenta will support a number of shops, cafes, a gym and business centre.
Adrian Hill, director of Highbridge Properties PLC said: "When I first saw this site it reminded me of London Docklands in the early years – so much potential and so close to the city centre. Magenta is a very compelling option for businesses, boasting superb connectivity, infrastructure and value for money.
"As the site can accommodate large modern floorplates, Magenta offers flexible and bespoke solutions which can be tailored to meet a company’s exact needs."