Business adviser Debbie Assinder will be heading up the hub at Innovation Birmingham, where Enterprise Nation will organise targeted events, support and workshops for local businesses.
According to statistics from national enterprise campaign StartUp Britain, Birmingham is the most entrepreneurial city outside of London, with 14,153 companies registered in 2015 alone.
Emma Jones, founder of Enterprise Nation, said: "The world of business has changed. More people than ever before are starting businesses and this trend shows no sign of abating.
“As a consequence the support and business environment must adapt to offer on the spot help to ensure these firms can build sustainable profitability.
"Debbie is going to be our woman on the ground in Birmingham, tapping into the already-booming start-up community and creating a buzz around enterprise."
Debbie will be working with partners such as Innovation Birmingham, Birmingham City University, Art Business Loans, KPMG and IoD West Midlands to offer regular events, clinics and support.
She said: "Our mission is to help start-ups and small businesses build profitability whilst making the most of a skill or passion, whether they are high-powered tech firms or people looking to improve their work life balance while providing for their family.
"I've been working as an adviser in the city for 20 years, I know this economic environment, I know who the key players are and those who can help create change to support this new ecosystem.
“We will help small businesses get to grips with digital tools, make sales to big brands and raise their profile.
“This will be delivered through a basic utility of online support, plus lively events across the Midlands."