The Charles Church builder said it had delivered an "outstanding" performance in 2015 as conditions in the housing market were boosted by government measures, rising consumer confidence and record low mortgage rates.
Persimmon - the UK's biggest housebuilder by volumes - posted a 34% jump in pre-tax profits to £637.8m for 2015.
The York-based group added the housing market had remained buoyant in the new year so far, with the spring selling season seeing private sales lift 13% on a year earlier.
Chairman Nicholas Wrigley said: "Persimmon delivered an outstanding performance in 2015, supported by improving customer sentiment and a mortgage market which is responding to customer demand."
Shares in the group rose 5% after the results.
The housebuilding sector bucked the volatile trends seen in the stock market last year, helped by favourable economic conditions, as well as a range of government support measures.
The government's Help to Buy programme enables purchases by buyers with deposits of only 5%, while it is also launching the Starter Homes initiative, which subsidises discounts of at least 20% for first-time buyers on newly-built properties.
Official figures earlier this month showed the average price of a home increased by £18,000 during 2015.
The Office for National Statistics said the typical UK property was worth £288,000, up from £270,000 on average in January last year - a 6.7% rise.
Persimmon, - which trades as Persimmon Homes, Charles Church and Westbury Partnerships - completed 8% more homes last year, totalling 14,572, with the average price rising by 4.5% to £199,127.
Its revenues rose 13% to £2.9bn.
The group said it sold 6,100 homes through Help to Buy in 2015.
Persimmon added its forward sales were 12% ahead of a year earlier at £1.68bn.
Charlie Campbell, analyst at Liberum, said Persimmon's results were better-than-expected.
But he cautioned the referendum on Britain's European Union membership could hit the housing market, albeit temporarily.
He said: "It would be reasonable to assume some slowing of sales ahead of that date due to general uncertainty, regardless of the eventual outcome.
"Houses are, after all, high-ticket items and the timing of purchases can be somewhat discretionary. We would expect uncertainty to pass after the event, so any disruption to sales is likely to prove relatively short-lived."
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